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Infectious Diseases
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Pneumonia
Reviewed by Anthony W Chow, MD, FRCPC, FACP
Best Health Guide. April 2000.
Last modified November 1, 2001
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BEST HEALTH BRIEF
Basics
Pneumonia is a short-term inflammation of the lung that is caused by an infection.
  There are two types of pneumonia: community-acquired and hospital-acquired (also called nosocomial). The first form is transmitted between people in a community, while hospital-acquired pneumonia is spread between patients in the hospital. As many infectious organisms tend to thrive in either, but not both of these environments, your doctor will try to figure out where you were infected in order to determine which organism is likely to be responsible for your pneumonia.

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Causes
Pneumonia often follows an infection of the upper respiratory tract (the nasal passages, for example) when the body's normal defenses are weakened. [FIGURE 1]
  Under normal circumstances, large bacterial particles are filtered out in the nasal passages. If smaller particles are inhaled, the body triggers a cough or sneezing reflex to force them back out. Tiny particles that bypass these sensors are then trapped in a blanket of mucus, and are moved out of the lungs by the beating movements of tiny, hairlike cells called cilia. Bacteria and other organisms that manage to avoid this defense system are attacked by white blood cells launched by the immune system. However, respiratory infections such as influenza or a cold can alter the mucus blanket and create an environment that favors the growth of bacteria. Other times, diseases such as HIV or cancer weaken the immune system, preventing the body from effectively fighting the bacterial and viral particles that bypass the respiratory defenses.
Organisms can reach the airways in a number of ways, including being inhaled or moving from other areas of the body.
  Sometimes the organisms that cause pneumonia are directly inhaled from the environment. More commonly, however, they move into the lungs from the areas around the mouth and in the throat, where they normally thrive without causing any harm. Sometimes, infections from other areas of the bodysuch as the heart or veinscan move into the lungs and cause pneumonia.
 
Figure 1. Pneumonia infection and fluid accumulation
A weakened immune system will allow for bacteria and other organisms that enter the airways of the lungs to cause an infection. Fluid will then accumulate in the lungs, leading to symptoms such as cough, shortness of breath, and chest pain. [PLAY]

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Symptoms
Pneumonia can produce a wide range of symptoms, including a dry or productive (mucus-producing) cough, shortness of breath, chills, and chest pain. [TABLE 1]
  Specific symptoms are often associated with the particular organism causing the infection. For example, the organism Streptococcus pneumoniae, which is responsible for about two-thirds of all cases of pneumonia, may cause an infection that comes on very abruptly, and is accompanied by fever, chills, chest pain, and rusty or pink mucus. On the other hand, a less typical pneumonia (caused by the organism Mycoplasma pneumoniae) might come on slowly, with headache, a general feeling of illness, a low-grade fever, and a dry cough.
Symptoms in the elderly can be less specific, including such things as rapid breathing and a low-grade fever.
  Symptoms in the elderly may be difficult to recognize since they differ significantly from the most typical pneumonia symptoms. Rapid breathing (tachypnea) is probably the most important sign of a respiratory tract infection in an elderly person. Pain in the upper part of the abdomen is also common, as is mental confusion.
Your doctor will rule out other conditions, such as bronchitis or heart problems, that produce similar symptoms.
  Symptoms similar to those of pneumonia may be found in bronchitis, substance abuse, drug reactions, blood clots in the lungs (pulmonary emboli), heart failure, and certain forms of lung cancer. Symptoms of these conditions, however, tend to be milder than those associated with pneumonia.

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Risk Factors
Although pneumonia can affect all age groups, it tends to be more severe among the elderly, the very young, and people with certain coexisting illnesses. [TABLE 2]
  Because a weakened immune system interferes with the body's ability to protect itself against bacteria that enter the airways of the lungs, people with immune diseases are at high risk for pneumonia. This includes people actively infected with the human immunodeficiency virus (HIV), those with cancer and receiving chemotherapy, and organ transplant patients. Other illnesses such as liver or kidney disease, stroke, and heart disease also increase the risk for pneumonia. Additionally, pneumonia can occur after a chest injury or surgery. Smoking and alcohol or drug abuse also tend to increase a person's risk for pneumonia.
Visiting or living in certain locales can increase your chances of getting pneumonia. [TABLE 2]
  Studies show that people who reside in or have recently traveled to the Southwest or the Ohio-Mississippi Valley are more likely to encounter organisms that can cause rare forms of pneumonia, as are people who have recently stayed in hotels. Exposure to birds or farm animals can also increase a person's risk of acquiring pneumonia.

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Diagnosis
Your doctor will ask you about past illness and other problems to determine what is causing your symptoms.
  You should tell your doctor about any illnesses you have, if you've recently been exposed to a person with HIV, or if you've experienced any sort of lessened consciousness, impaired gag reflex, or vomiting. Alcohol or intravenous drug abuse, smoking history, a recent hospital or hotel stay, and exposure to birds and farm animals can also provide important information about the potential source of your infection.
  You should also tell your doctor if you have had a recent viral infection, flulike symptoms, or have recently traveled to the Southwest or Ohio-Mississippi Valley.
A physical examination helps the doctor to diagnose pneumonia. It can also help determine the severity of the disease.
  Your doctor will listen to your heart, lungs, and chest through a stethoscope for evidence that pneumonia is the likely cause of your infection. For example, a crackling or bubbling sound in the chest (rales) or rumblings in the chest that indicate fluid build-up (rhonchi) are signs that would indicate pneumonia rather than bronchitis (which is characterized by crackles and wheezing chest sounds). Another sign of pneumonia is a dull thud as the result of light tapping on the chest rather than the hollow drumlike sound that normally occurs.
  The doctor will record your vital signs, which include temperature, pulse rate, blood pressure, and breathing speed. Up to 80% of people with pneumonia have abnormal vital signs. Additionally, central nervous system signs such as mental confusion, in combination with an extremely high or low fever, rapid heart rate, and labored and heavy breathing, can indicate that pneumonia is severe enough to constitute a medical emergency.
Chest x-rays are not always required to confirm a diagnosis of pneumonia.
  Most people with mild pneumonia can be effectively treated without having a chest x-ray taken first. However, in people with moderate to severe pneumonia, a chest x-ray is often taken to determine the extent of disease and the need (if any) for additional testing. X-rays are especially useful in people with weakened immune systems since they can help assess whether or not pneumonia or some other illness is responsible for symptoms. Chest x-rays can also be used to show complications of disease, such as a build-up of pus in the lungs (emypemas) or abscesses.
Laboratory tests are sometimes required to confirm a diagnosis of pneumonia.
  Laboratory testing is not usually necessary for people with mild disease. Because treatment is started immediately, tests will only be ordered if a medication does not help, or to help distinguish between bacterial and viral pneumonia in severely ill patients. Lab Tests are also useful for people whose pneumonia is caused by an organism that is resistant to standard antibiotic treatment.
  Relevant laboratory tests include such procedures as a complete blood cell count (CBC), which measures the number and type of white blood cells in the blood, a cold agglutinin test, which indicates if certain antibodies are present as a result of infection, a mucus (sputum) culture, and a Gram stain, which involves adding a stain to culture to help identify possible causes of infection. Patients with breathing difficulties may be given tests that are used to assess the lungs' ability to move oxygen into the blood. These include pulse oximetry and the arterial blood gas test.

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Prevention and Screening
Get a pneumococcal vaccination and an annual influenza vaccination if you are at risk for pneumonia.
  Influenza increases the risk of pneumonia because it significantly weakens the natural defenses of the respiratory system against invasion by bacteria and other organisms. That's why it's important to have an annual influenza vaccination, especially if you are age 65 or over, have a chronic illness, or have a weakened immune system. Pneumococcal vaccinations have also proven effective in preventing pneumonia, and vaccinations are recommended for people at high risk. Unlike the influenza vaccine, which must be received annually, the pneumococcal vaccine lasts for over six years.
Caregivers or family members of someone with pneumonia should wash their hands frequently to prevent transmission.
  Although there is no guarantee that a family member or a caregiver won't catch pneumonia, the risk can be lowered with frequent handwashing before eating, before touching the eyes or nose, and after going outside. Eating foods that are rich in the antioxidant vitamins C, E, and beta-carotene, such as dark cruciferous vegetables (broccoli, carrots) and orange or yellow fruits and vegetables (oranges, mangoes, apricots), may also help to boost the immune system. Additionally, drinking lots of fluids to keep the mucus membranes hydrated can reduce the risk of bacterial or viral transmission.

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